involvement of gabaergic system in increased pentylenetetrazole-induced seizure threshold in cholestatic mice

نویسندگان

mir hadi khayat nouri

department of pharmacology, school of veterinary medicine, islamic azad university, tabriz, iran vahab babapour

department of physiology, faculty of veterinary medicine, tehran university morteza samini

department of pharmacology, faculty of medicine, tehran university of medical sciences/ tehran university, tehran, iran

چکیده

gamma-aminobutyric acid (gaba) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. pentylenete-trazole (ptz), a convulsant agent, partly acts via anion channel of gabaa receptor. ivermectin, an antiparasitic agent and a gabaa agonist, has anticonvulsant effect in animal seizure models. cholestasis increases the threshold of ptz-induced clonic seizure in mice. the object of this study was to clarify the involvement of gabaergic pathways in increasing ptz-induced seizure threshold (st) in cholestatic mice. the result of this study showed that cholestasis increases clonic st three days after surgery while sham-operated control (soc) and unoperated control (uoc) groups did not show any alteration in clonic st. bicuculline, a gabaa antagonist, reversed but ivermectin increased the clonic st in uoc, soc and bile duct-ligated mice, respectively. in conclusion, our results showed that: (1) acute cholestasis is associated with an increase in ptz-induced clonic st in mice and this phenomenon may be the result of reinforcement of gabaergic system, and (2) gaba plays a physiological role in regulation of st.

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Involvement of GABAergic System in Increased Pentylenetetrazole-Induced Seizure Threshold in Cholestatic Mice

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عنوان ژورنال:
iranian journal of pharmaceutical sciences

جلد ۳، شماره ۱، صفحات ۲۵-۳۰

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